Rapid development of thymic neuroendocrine carcinoma despite transcervical thymectomy in a patient with multiple endocrine neoplasia type 1

Rapid development of thymic neuroendocrine carcinoma despite transcervical thymectomy in a patient with multiple endocrine neoplasia type 1

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Thymic neuroendocrine (NE) tumors are a rare manifestation of multiple endocrine neoplasia syndrome type 1 (MEN-1).They Baby Toys are malignant and aggressive tumors and form a major cause of mortality in MEN-1.Transcervical thymectomy (TCT) at the time of parathyroid surgery for primary hyperparathyroidism (PHPT) in MEN-1 usually prevents thymic NE tumors.We report a 56-year-old nonsmoker male with sporadic MEN-1 who presented with thymic NE carcinoma developing rapidly within a span of 8 months after subtotal parathyroidectomy and TCT for PHPT.

We present a brief review of literature on this rare NE malignancy, focusing on its occurrence despite TCT.This case highlights the fact that thymic NE carcinoma may develop even after TCT in MEN-1.Regular surveillance for these aggressive thymic NE tumors is Armored Opto Sensor Cable mandatory even after TCT in MEN-1 setting.